Fig. 1. Extracellular Vesicle' Origin, Cargo and Clinical Applications. Extracellular Vesicles secreted by neurons and glial cells are able to cross the brain blood barrier (BBB) through a mechanism known as trans-cytosis and their impact on target cells depends by the cargo that they shuttle. Thus, the EVs could represent a diagnostic and functional biomarker as well as suitable therapeutic agents in neurological diseases. Source: Servier Medical Art by Servier and modified under the following terms: Creative Commons Attribution 3.0 Unported license (CC BY 3.0).